Ultramarathon and Renal Function: Does Exercise-Induced Acute Kidney Injury Really Exist in Common Conditions? The study used data collected from Ultra-Marathon runners who completed the 2017 edition of the 120 km long “Infernal Trail”. The samples were collected within 2 hours before the race (start) and immediately after the race (destination). The measurements of serum creatinine, Cystatin C, creatine kinase and urinalbumin were carried out.Acute kidney damage was divided into the Rifle criteria.The “damage risk” has been defined as the increase in serum creatinine or decrease in the glomerular filtration rate of more than 25%.The kidney damage was defined as 2 × serum creatinine or decrease in the glomerular filtration rate> 50%. These two categories of kidney damage were combined to calculate the overall incidence in the target. The glomerular filtration rate was estimated by two methods using the measurement for serum creatinine and the measure of Cystatin C.To define renal damage, urinary biomarker \ [neutrophilic gelatinase-associated lipocaline (NGAL) ] were used. A sample of 24 trapped finishers without the use of non-steroidal anti-inflammatory medicinal products was investigated.Depending on the method used to calculate the glomerular filtration rate, a prevalence of kidney damage was observed from 0 to 12.5%. The biomarkers for kidney damage in urine were increased after the race, but without significant decrease in the glomerular filtration rate.
Our study showed a very low prevalence of kidney damage and no evidence that ultra-seven can not cause important kidney damage without the use of NSAIDs with well-hydrogenated subjects. Whether the increase in biomarkers for kidney damage in urine after the race reflects a structural renal injury or a simple metabolic adaptation to strenuous loads, must be clarified in further studies. The whole study can be found under https://www.frontiersin.org/articles/10.3389/FSPOR.2019.00071/Full