Running a marathon from -45°C to +55°C in a climate chamber: a case study The German extreme sportsman Marcel Heinig has run a marathon in the climate chamber and overcome the temperature difference of 100 ° C.Start was at - 45 ° C and the end at + 55 ° C. Previous and during the marathon various blood and urine values were determined as well as the body temperature on the surface and in the body interior measured.The body core temperature remained constant while the temperatures on the body surface made massive fluctuations. The laboratory values showed a massive increase in growth hormone (+ 391%), prolactin (+ 221%), Renin (+ 1145%) and Aldosterone (313%). All results can be found under https://www.dovepress.com/running-a-marathon-from–45degc-co-55degc-in-a-climate-chamber-a-case–peer-reviewed-FullText-Article OAJSM