Blood cardiac biomarkers responses are associated with 24 h ultramarathon performance. The clinical significance of the response of heartbiomarkers in ultra-runners is not fully clarified as the runs in terms of route and duration vary and the competitors modulate the running intensity according to individual travel capacity. The aim of this study was to examine the relationship between the self-chosen training intensity and heartbiomarkers by comparing experienced (n = 11) and inexperienced (n = 14) runners, which a 24-hour ultramarathon with significant differences in performancecan finish.Heartbiomarker (CKMB / Totalck, CTNT and NT-Probnp), inflammatory markers (leukocytes and CRP) and cortisol were analyzed before and after a 24-hour ultramarathon. Experiencing runners ended the race with a significant longer distance as inexperienced runners (158.8 ± 15.8 versus 116.8 ± 10.3 km). The evaluation showed a significant interaction between time and performance level with a greater increase in CTNT, NT-Probnp and Cortisol in the group of experienced runners.CKMB / Totalck decreased, while leukocytes and CRP climbed in both groups.Correlations between traveled distance and cortisol, CKMB, CTNT or NT-Probnp were found.Cortisol and NT-Probnp were also significantly correlated. Although there are no clear indications of a heart risk, if cardiac biomarkers are compared with clinical limits, cardiale biomarkers are associated with the mileage and the reaction of the hypophysen adrenal tongue system.
For experienced runners, higher levels of cardiac organic markers and cortisol indicate a hemodynamically stronger-stressed heart for prolonged endurance training. The whole article can be found under https://pubmed.ncbi.nlm.nih.gov/31338451/