Exercise, Obesity and CNS Control of Metabolic Homeostasis: A Review The American John Kelly Smith has thought about the way in which the central nervous system regulates metabolic homeostasis in normal weight and obese rodents and humans. His work is a very complex overview of the homeostatic contributions of neurons in the hypothalamus, the midbrain and the limbic structures, the PONS and the Area PostRema, the Nucleus Tractus Solitarius and the Vagus Core, as well as details of how these brain regions react to circulating orexigen hormonesGhrelin, and anorexigene hormones such as glucagon-like peptide 1 and leptin. The work gives an insight on how high-intensive training can improve homeostatic control in overweight and obese patients.
Finally, the work shows suggestions on how further advances can be made in the control of the current pandemic of obesity and diabetes. The whole article can be found under https://internal-journal.frontiersin.org/articles/10.3389/fhys.2018.00574/full