Cardiovascular stress biomarker assessment of middle-aged non-athlete marathon runners The cardiovascular security of marathon runs remains unclear.This study examined the impact of a marathon on the profile of biomarkers for cardiovascular burdens associated with transthoracic echocardiography.Thirty-three healthy male amateur runners, which were ≥ 50 years old (average age 57 ± 7 years), were examined. Venous blood samples were won in front of the marathon shortly after the race, 2-4 days and 7 days after the marathon.The plasma concentrations of highly sensitive heart troponin I (HS-CTNI) and endothelin-1 were measured.The N-terminal Pro-B-type natriuretic peptide was measured using electrochemiluminescence. Each participant had a transthoracic echocardiography before and immediately after the race. It showed a strong increase in biomarkers after the race, which was normalized after 2-4 days and remained in the normal range after 7 days. Runners with intensive training programs (> 169 km / month) after the race had a lower HS-CTNI. There were a decline in the left atrial volume volume and an increase in the maximum right atrial volume. Changes in the Doppler indices of the diastolic function were observed, which indicate a change in left ventricular relaxation. A marathon is associated with a strong and significant increase in biomarkers.
However, the profile of these changes do not indicate an irreversible myocardial damage together with the echocardiographical parameters. The study can be found under https://pubmed.ncbi.nlm.nih.gov/30744458/